Association between promoter polymorphisms of the LIFR gene and schizophrenia with persecutory delusion in a Korean population

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Association between promoter polymorphisms of the LIFR gene and schizophrenia with persecutory delusion in a Korean population.

Schizophrenia has been associated with an imbalance in inflammatory cytokines. Leukemia inhibitory factor receptor α (LIFR) is an integral component of the glycoprotein 130-LIFR signaling complex, which participates in signal transduction by members of the interleukin (IL)-6 cytokine family. The aim of this study was to investigate whether genetic...

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15 صفحه اول

PM447. Association between coding single nucleotide polymorphisms in ADAMTS20 gene and schizophrenia in a Korean population

Cognitive deficits (CD) in schizophrenia are recalcitrant to treatment as usual. Whilst there has been considerable interest in recent years for evaluating the efficacy of cognitive remediation (CR) programs in schizophrenia at research settings, scant attention has been paid to evaluate the effectiveness of CR programs at everyday clinical practice settings. Method: We evaluated retrospectivel...

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Association between FAT Gene and Schizophrenia in the Korean Population

OBJECTIVE The aim of this study was to investigate the genetic association of the FAT gene with schizophrenia in the Korean population, as well as analyzing the association of FAT gene with clinical variables. METHODS Four variants within the FAT gene were investigated in 189 patients with schizophrenia and 119 healthy controls (rs2306987 A/C, rs2306990 T/C, rs2637777 G/T, and rs2304865 G/C)....

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Lack of Association between Interleukin-10 Gene Promoter Polymorphisms with HIV Susceptibility and Progression to AIDS

Background & Objective: Interleukin (IL)-10 is an important anti-inflammatory and immunomodulatory cytokine. Some authors believe that single nucleotide polymorphisms (SNP) in the promoter region of the IL-10 gene have been associated with susceptibility to HIV infection and progression to AIDS, but its role is not clearly defined yet. The present study was undertaken to evaluate the a...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2011

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2011.618